Continuous flow hydrogenation with Pd complexes of pyridine‐benzotriazole ligands

Abstract

AbstractThe use of continuous flow systems in chemical synthesis provides great advantages in terms of sustainability, efficiency, and safety. The ability to control reaction parameters such as temperature, pressure, and catalyst exposure in flow system enables rapid optimization of reaction conditions. In the present study, palladium complexes of 1‐(piridin‐2‐il)‐1H‐benzo[d][1,2,3]triazol, N‐((1H‐benzo[d][1,2,3]triazol‐1‐il)metil)piridin‐2‐amin, and (1H‐benzo[d][1,2,3]triazol‐1‐yl)(pyridin‐2‐yl)methanone ligands were synthesized and characterized. The catalytic activities of complexes are investigated in the hydrogenation of various alkenes such as styrene, cyclohexene, and 1‐octene under continuous flow conditions. The complexes showed very high activity at 10‐bar H2 pressure and 50°C for short periods of 5–10 min. The catalysts reused for 10 cycles with no significant loss of catalytic activity.