Abstract
Catalytic enantioselective transformations provide well-established and direct access to stereogenic synthons that are broadly distributed among active pharmaceutical ingredients (APIs). These reactions have been demonstrated to benefit considerably from the merits of continuous processing and microreactor technology. Over the past few years, continuous flow enantioselective catalysis has grown into a mature field and has found diverse applications in asymmetric synthesis of pharmaceutically active substances. The present review therefore surveys flow chemistry-based approaches for the synthesis of chiral APIs and their advanced stereogenic intermediates, covering the utilization of biocatalysis, organometallic catalysis and metal-free organocatalysis to introduce asymmetry in continuously operated systems. Single-step processes, interrupted multistep flow syntheses, combined batch/flow processes and uninterrupted one-flow syntheses are discussed herein.
Highlights
The enantioselective synthesis of chiral molecules plays an outstanding role in the pharmaceutical industry.[1]
In the following three sections, contributions on continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients (APIs) and their advanced intermediates are categorized on the basis of the nature of chiral catalysis employed in the key synthetic steps to introduce asymmetry
Over the past few years, significant progress has been achieved in the continuous flow asymmetric synthesis of chiral APIs and their advanced intermediates
Summary
The enantioselective synthesis of chiral molecules plays an outstanding role in the pharmaceutical industry.[1] This can primarily be explained by the fact that the majority of drugs contain chiral molecules as active pharmaceutical ingredients. Chemistry at the University of Szeged (Hungary) and obtained his MSc in 2009. After conducting postdoctoral research at the University of Szeged/. Ötvös where he is currently serving as an FWF Project Leader at the University of Graz (CC FLOW labs) as well as a Senior Scientist at Research Center Pharmaceutical Engineering GmbH. His research interests are focused on the combination of continuous flow chemistry, synthetic organic chemistry and catalysis with a special emphasis on the synthesis of APIs
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