Abstract
Interest in the continuous manufacturing in the pharmaceutical industry for the production of Active Pharmaceutical Ingredients (API’s) has greatly increased in recent years. This has led to a variety of studies on continuous processing including a large number of studies in the area of continuous crystallization. While various potential crystallizer configurations exist, the vast majority of work in this area has focused around the Mixed Suspension Mixed Product Removal (MSMPR) crystallizer. In this review, MSMPR crystallizers will be described along with their use in continuous API manufacture.
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