Continuity of Care Follow-up Update: Results of a Consensus Multidisciplinary 8-Week Postradiation Tumor Response Evaluation Algorithm

Abstract

these cases included nerves innervating the involved skin dermatome but not SBG. Seventy-three percent of observed patients and 31% of irradiated patients with MEPNI recurred. Two years RFS in nerves (94% vs 25% respectively; hazard ratio [HR] 0.06, 95% confidence interval [CI] 0.006-0.5, PZ.01) and DFS (73% vs 40%, HR 0.32, 95% CI 0.1-0.99, PZ.05) rates were significantly higher in the treated MEPNI pts compared with the observed. Twenty-seven of 37 patients (73%) diagnosed with MFPNI were observed; the rest were treated with RT. Patients with MFPNI had a low rate of neural and overall failure, and there was no significant benefit to irradiation in these patients. Conclusion: Our study demonstrates the patterns of failure and the role of RT for patients with HNCSCC, GCNI, MEPNI. Awareness of these patterns and knowledge of the cranial nerves anatomy should serve as guidelines for target volume delineation. In patients with MEPNI, RT is associated with fewer gross perineural recurrences and better DFS, compared with the observation strategy. Author Disclosure: E. Sapir: None. A.A. Tolpadi: None. S. Samuels: None. M. Ibrahim: None. E. Elalfy: None. J.B. McHugh: None. A. Eisbruch: None.