Abstract
Paramagnetic versions of the CLEAR supports were prepared by direct incorporation of magnetite particles during suspension polymerization of allylamine, trimethylolpropane ethoxylate (14/3 EO/OH) triacrylate, and trimethylolpropane trimethacrylate. Swelling studies in a broad range of solvents showed comparable swelling of composite beads and regular CLEAR beads. The application of the composite beads as the support in solid-phase synthesis of peptides and small organic affinity ligands is described. Adequate stability of the beads and retention of their magnetic properties were observed throughout the synthesis steps.
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