Abstract
Acute circulatory disorders are commonly associated with systemic inflammatory response (SIRS) and sepsis. During sepsis, microcirculatory perfusion is compromised leading to tissue hypoperfusion and potentially to multiple organ dysfunction. In the present study, acute lung injury (ALI), one of the major causes leading to SIRS and sepsis, was experimentally induced in six female pigs. To investigate the progress of body temperature distribution, measurements with a long-wave infrared camera were carried out. Temperature centralization was evidenced during ALI owing to impairments of peripheral perfusion. In addition, statistical analysis demonstrated strong correlations between (a) standard deviation of the skin temperature distribution (SD) and shock index (SI) (p<0.0005), (b) SD and mean arterial pressure (MAP) (p<0.0005), (c) ΔT/Δx and SI (p<0.0005), as well as between (d) ΔT/Δx and MAP (p<0.0005). For clarification purposes, ΔT/Δx is a parameter implemented to quantify the spatial temperature gradient. This pioneering study created promising results. It demonstrated the capacity of infrared thermography as well as of the indexes, SD and ΔT/Δx, to detect impairments in both circulation and tissue perfusion.
Highlights
Acute circulatory disorders belong to the major causes of death
There are several diseases leading to systemic inflammatory response syndrome (SIRS) and sepsis, acute lung injury (ALI) and pulmonary infection are still considered the major causes of them [4]
Owing to consequences of acute respiratory distress syndrome (ARDS), three animals died before the end of the animal trial but all hitherto data were analyzed
Summary
Acute circulatory disorders belong to the major causes of death. Sepsis is a severe disease characterized by the presence of both infection and SIRS. It might develop into severe sepsis or septic shock. While the former corresponds to an aggravated sepsis by acute organ dysfunction, the latter corresponds to a severe sepsis plus hypotension, which is not reversed with fluid resuscitation [1,2,3]. There are several diseases leading to SIRS and sepsis, acute lung injury (ALI) and pulmonary infection are still considered the major causes of them [4]. Several pathophysiological similarities and links have been stated by diverse studies [5]
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