Abstract
We aimed to conduct a meta-analysis investigating the association between consumption of vegetables and fruits and breast cancer survival. A comprehensive search of the PubMed and EMBASE was performed from the inception to September 30, 2016. The summary hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a random effects model. Ten studies, with a total of 31,210 breast cancer cases, were included in the meta-analysis. The summary HRs (95% CIs) of overall survival (highest vs. lowest) were 1.08 (0.88–1.33; I2 = 41.1%) for pre-diagnostic intake of vegetables and fruits combined, 0.96 (0.71–1.30; I2 = 48.4%) for vegetables alone, and 0.83 (0.67–1.02; I2 = 0) for fruit alone. No significant risk associations of overall survival were found for post-diagnostic intake of vegetables and fruits. Line dose-response analyses indicated the likely results for both pre- and post- diagnostic dietary intake. No significant association was found between intake of vegetables and fruits and breast cancer-specific mortality. In addition, intake of cruciferous vegetables was not associated with death from breast cancer. Our findings indicated a borderline inverse association between pre-diagnostic intake of fruit and overall survival of breast cancer, whereas intake of vegetables was not associated with survival.
Highlights
We aimed to conduct a meta-analysis investigating the association between consumption of vegetables and fruits and breast cancer survival
We have evaluated the association between intake of vegetables and fruits and breast cancer outcomes using a meta-analysis of previously published studies
Results of this meta-analysis suggest that intake of vegetables and fruit is not significantly associated with total and specific death from breast cancer
Summary
We aimed to conduct a meta-analysis investigating the association between consumption of vegetables and fruits and breast cancer survival. No significant risk associations of overall survival were found for post-diagnostic intake of vegetables and fruits. No significant association was found between intake of vegetables and fruits and breast cancer-specific mortality. Researchers have focused on the beneficial effects of consumption of vegetables and fruits (VF) on the prevention of cancers, including breast cancer[2,3]. Radiation dose, city, BMI, smoking status, alcohol habits, education level, age at menarche, age at first birth, parity, breastfeeding, menopausal status, history of breast adenoma, Age, energy intake. State of residence, menopausal status, smoking, stage, alcohol, HRT, interval between diagnosis and diet assessment, energy intake, breast cancer treatment, BMI, physical
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
