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Abstract
Background. The effect of acyclovir on inpatients with acute herpetic pain has been examined in only few studies.Aim. To examine the effect of acyclovir on intensity and course of herpes zoster-associated neuralgia in hospitalized patients.Method. Two groups of patients (50 each) hospitalized for acute herpes zoster in 1983/84 (before acyclovir was available) and in 1989/90 (when acyclovir was given for at least 5 days intravenously) were evaluated for pain and consumption of pain medication.Results. The score for pain intensity did not differ significantly in acyclovir-treated patients compared to patients who did not receive the drug.Conclusion. This study fails to demonstrate a beneficial effect of acyclovir on acute herpetic neuralgia.
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