Abstract
We investigated the acute effect of a single dose of dried-bonito broth (DBB) on peripheral blood flow using a laser Doppler blood flow meter. In a randomized, double-blind, crossover, placebo-controlled study, 19 healthy female subjects ingested DBB (4900mg) or placebo. The peripheral blood flow was measured before ingestion and at 5, 10, 15, 20, 25, 30, 45, and 60min after ingestion of the test diet. Blood flow significantly increased after DBB ingestion, and th ea rea under the blood flow-time curves calculated up to 60min (AUC0‐60 )f or the ingestion with DBB was significantly higher than that for the placebo ingestion (p < 0.001). Following consumption of lower dose of DBB (2450mg), an increase in peripheral blood flow was observed and that the AUC0‐60 after subjects consumed DBB was significantly higher than that after they consumed the placebo (p < 0.01). The mean AUC0‐60 fo rt he treatment with 4900mg DBB was about 2 times that for 2450mg DBB, suggesting that an orally administered single dose of DBB might have an acute dose-dependent effect on peripheral blood flow.
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