Abstract
We studied the health benefits of acute cranberry beverage consumption on oxidative damage, inflammation, and anti‐bacterial adhesion activity of urine in healthy humans. Six males and 6 females (18–35 yr old; BMI 19–25 kg/m^2) consumed 15.2 oz placebo, cranberry extract beverage (CEB) and low calorie cranberry juice cocktail (LCJC) in a randomized, cross‐over, double‐blind, placebo‐controlled experimental design. Washout between beverages was 1 week. Blood was collected at 0, 2, 4, 8 and 24 h after beverage consumption for measuring oxidative and inflammatory biomarkers. Urine was collected at 0, 0–3, 3–6, 6–9, 9–12 and 24 h post‐intervention. Consumption of CEB elevated (P < 0.05) blood superoxide dismutase (SOD) and glutathione peroxidase (GPx), and decreased (P < 0.05) plasma nitric oxide (NO) compared to placebo. LCJC consumption increased (P < 0.05) SOD and reduced‐glutathione (GSH), and decreased (P < 0.05) NO. Neither cranberry beverage significantly changed concentrations of plasma 8‐hydroxydeoxyguanosine, inflammatory cytokines and total antioxidant capacity. At 0–3 h, participants who consumed cranberry beverages had higher (P < 0.05) ex vivo anti‐adhesion activity against P‐fimbriated E. coli compared to placebo. An acute dose of cranberry beverages reduced oxidative and inflammatory biomarkers and improved inhibition of bacterial adhesion by urine. Funded by Ocean Spray Cranberries Inc.
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