Chronic Consumption of High Polyphenol Content Cranberry Beverage Improves Phenolic Acid and Flavonoid Bioavailability in Healthy Overweight Humans

Abstract

We studied phenolic acid and flavonoid bioavailability after cranberry beverage consumption in healthy overweight humans. Men and women (30-70 y; n=78) with abdominal adiposity (BMI 27-35; waist:hip >0.8 (women) or >0.9 (men); waist:height 蠅0.5) consumed 15.2 oz placebo or high polyphenol cranberry extract beverage (CEB) daily for 8 wk in a randomized, double-blind placebo-controlled trial. Urine was collected 24 h prior to and 0-8 h after oral glucose challenge following a single dose (acute response) and 8 wk daily consumption (chronic response). Compared to placebo, CEB elevated (P<0.05) epicatechin, caffeic, p-coumaric, ferulic, sinapic and 4-OH-3-MeOH-phenylacetic acids 0-8 h following a single dose and after 8 wk intervention; quercetin and 3,4-OH-phenylacetic acid were elevated (P<0.05) after 8 wk intervention. Concentrations of 6 anthocyanins (galactosides, glucosides, arabinosides of cyanidin and peonidin) were elevated (P<0.05) 0-8 h following a single dose and 8 wk CEB intervention compared to baseline levels. CEB consumption for 8 wk increased (P<0.05) proanthocyanidin A2 in 24 h samples compared to placebo; epicatechin, gentisic, caffeic, p-coumaric, ferulic, sinapic, 4-OH-3-MeOH-phenylacetic and 3,4-OH-phenylacetic acids were also elevated (P<0.05) in 24 h samples compared to baseline. Cranberry phenolic acids and flavonoids are bioavailable in healthy overweight humans. Supported by Ocean Spray Cranberries Inc and USDA.