Abstract
An influence of the ultrasound beam on the process, dissolution of solids in liquid solvents is considered: influence of frequency, intensity, velocity of acoustic vibrations, cavitation and acoustic flows on mass transfer process. Experimental researches show that the intensification of dissolution process of solids in liquid solvents under action of ultrasound is influenced by acoustic flows, microflows and under influence of cavitation bubbles. Development of new efficient equipment for solution requires the development of calculation methods of dissolution processes of solids in liquid solvents under conditions of ultrasonic irradiation. Such methods should take into account the characteristics of ultrasonic generators, irradiation frequency of ultrasonic vibrations, power and intensity of ultrasonic vibrations. Mathematical model of dissolution process of the granule is constructed. It identifies the change of size of the granule over time under influence of the source of ultrasonic irradiation. Mathematical model consists of three differential equations used to calculate depending on the ratio of the granule size and the maximum turbulence scale of acoustic flows and for cavitation. The mathematical model will enable use in conducting numerous studies as a basis of equipment calculation methods for dissolution process of granular material.
Highlights
Dissolution process of solids in liquid solvents are widely used in biotechnology and pharmaceutical industries to prepare nutrient medium components, semi-finished products and auxiliary products at different stages of technological production of finished products.Dissolution is considered as unauthorized diffusion kinematic process that occurs in the collision of dissolved material and solvent [1]
Dissolution rate of solid granules in water in the face of acoustic flows depends on the ratio of the granules and the maximum turbulence scale λ0, defined by the formula [18]: b3 4 λ0 = ρ3 4ε1 4, (14)
The analysis shows that intensification is influenced by acoustic flows and microflows and by the occurrence of cavitation bubbles
Summary
Dissolution process of solids in liquid solvents are widely used in biotechnology and pharmaceutical industries to prepare nutrient medium components, semi-finished products and auxiliary products at different stages of technological production of finished products. 4. Dissolution in a changing direction and flow rate of the liquid associated with inertia of the particles, such as: – Dissolution using mechanical vibrations. One of the promising areas for intensification of dissolution process of solids in the liquid solvents are use of acoustic vibrations, or, as they are traditionally called, ultrasonic vibrations [6]. Ultrasonic vibrations have an influence on dissolution process through the frequency, intensity, velocity of acoustic vibrations, and promote the mass transfer process due to the emergence of cavitation and acoustic flows in the liquid. The choice of acoustic device for dissolution process of solids in liquid solvents and modes of its operation necessitates the study of the influence of ultrasound treatment factors by developing a mathematical model of the process [7, 8]
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