Abstract
Excess bilirubin in blood can provoke hepatic damage and related malfunctions. Hereby we designed and constructed a novel bilirubin adsorbent, called chitin/graphene oxide (Ch/GO) composite aerogel beads, for efficient, fast and safe removal for bilirubin. The Ch/GO aerogel beads were prepared from chitin and GO in a NaOH/urea aqueous solution, followed dried by supercritical carbon dioxide. The morphology, structure and properties of the Ch/GO composite aerogel beads were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and compressive strength measurement. The results indicated that GO was successfully bound to chitin matrix with enhanced surface area, thermal stability and mechanical strength. The adsorption capacity of Ch/GO composite aerogel beads for bilirubin was examined by UV–vis spectrophotometry. Moreover, batch adsorption results revealed that the Ch/GO composite aerogel beads showed excellent bilirubin adsorption capacity (484.1 ± 16.9 mg/g) and short adsorption equilibrium time (0.5 h) under optimized condition. Furthermore, the Ch/GO aerogel beads exhibited a lower hemolysis property and improved anticoagulant property. Hence, this work provided a new strategy to develop a novel blood compatible bilirubin adsorbent, which presented good application potential for bilirubin adsorption.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
