Abstract
In the fabrication of artificial soft tissues, novel biomaterials with the required properties are obtained by appropriately adjusting process parameters during material synthesis. One key step in finding the desired material is understanding the relationship between the process parameters and the material properties, and time-course experiments are typically conducted for this purpose. This article proposes a constrained varying-coefficient modeling method for such data in which expert knowledge is properly accommodated in the model estimation to make the modeling practically meaningful. The proposed model has a semiparametric structure and incorporates expert knowledge in the form of constraints on model coefficients. Estimation algorithms based on a smoothing spline and a weighted smoothing spline are also provided. Finally, the proposed method is compared with existing methods in a case study and a numerical study.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.