Abstract
Annotation. The purpose of the work is to analyze the scientific literature regarding the constitutional markers of urticaria and their prognostic significance. The analysis of modern scientific literature in the scientometric databases PubMed and MEDLINE is carried out. A review of the literature indicates that significant progress has been made in understanding the etiopathogenesis of urticaria in recent decades, with some clinical and anamnestic signs suggestive of adverse outcomes. However, identifying patients with the highest risk of complications remains an unresolved issue. In connection with the development and implementation in clinical practice of methods of genetic typing, much attention is paid to the search for genetic predictors of adverse course of this dermatosis. To date, phenotypic marker profiles that have been little modified over a lifetime and available for visualization in everyday clinical practice have not been properly considered in assessing the risk of urticaria. Modern anthropocentric approach to solving the problem of risk prediction in urticaria opens up the prospect of taking into account constitutional (personality-typological, somato-typological) and genetic factors that are the basis of psychobiological reactivity of the individual, determining individual variability of pathogenesis and clinical manifestations, patterns severity and frequency of complications.
Highlights
Urticaria is a disease associated with mast cell degranulation, blistering, itching, and angioedema in the absence of specific triggers [31]
The aim of the work is to analyze the scientific literature on the constitutional markers of urticaria and their prognostic significance
Some hereditary defects in the complement system lead to the development of hereditary urticaria, which is accompanied by the appearance of giant blisters
Summary
Urticaria is a disease associated with mast cell degranulation, blistering, itching, and angioedema in the absence of specific triggers [31]. The medical and social significance of this disease is due to its widespread prevalence, the development of the vast majority of people of working age, high-cost treatment and a significant reduction in the quality of life of patients [28]. The aim of the work is to analyze the scientific literature on the constitutional markers of urticaria and their prognostic significance
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