Abstract
Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM.
Highlights
Citrus medica L. var. sarcodactylis Swingle belongs to the genus Citrus (Rutaceae), and is commonly distributed in South and Southeast Asia
Various species of Citrus have been used as foods, and their fruits, leaves, and roots have been used as folk medicine or spice in Taiwan [1]
The fresh fruits of C. medica var. sarcodactylis were pulverized into powder and extracted five times
Summary
Citrus medica L. var. sarcodactylis Swingle belongs to the genus Citrus (Rutaceae), and is commonly distributed in South and Southeast Asia. Various species of Citrus have been used as foods, and their fruits, leaves, and roots have been used as folk medicine or spice in Taiwan [1]. Several anti-inflammatory compounds have been isolated from the stems and root barks of the titled plant [18]. A new sesquiterpene 1 (Figure 1) and thirty-two known compounds been characterized in the present work. 1) andhave thirty-two known compounds have been characterized in the present of is described .
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