Abstract
Werder and Hardin1,2 have reported that splenectomy prolongs the survival time of homologous skin grafts on CFW mice, and that application of consecutive, randomly selected homografts would produce permanent survival of homologous skin grafts on heterozygous CFW mice. In view of this unexpected finding and its possible significance to present theories of the mechanisms of homograft rejection, a similar investigation was made in a strain of non-inbred mice.
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