Abstract
Aim. Assessment of the prevalence of connective tissue dysplasia markers in women with primary knee and hip osteoarthritis.
 Methods. 203 females were examined in a cross-sectional study, with median age 58 years (55-62 years) and duration of post-menopause for 8 years (5.0-12.0 years). Severity of postmenopausal syndrome was defined by modified menopause index scores with the assessment of neurovegetative, metabolic and endocrine and psychoemotional symptoms. Backache and joint pain were assessed by visual analogue scale. Osteoarthritis was diagnosed according to clinical and radiologic criteria.
 Results. In 153 patients primary osteoarthritis stage 2-3 was diagnosed (group 1), group 2 included 50 patients without osteoarthritis. Screening for connective tissue dysplasia was performed by steps. At first, L.V. Solovyova’s phenotypic screening scale modified by T.F. Peretolchina was used, and cut-off score of 1.92 points was found in 6 (12%) patients without osteoarthritis and 44 (28.8%) in osteoarthritis group, that allowed suggesting connective tissue dysplasia. Then international M.J. Glesby phenotypic scale was used: 53 (34.6%) patients with osteoarthritis and only 1 (2%) subject without osteoarthritis had three and more phenotypic traits (χ2=18.925, р <0.001), that confirms connective tissue dysplasia. On step three, according to Russian guidelines on «Inherited disorders of connective tissue» (Russian scientific society of cardiology, 2012), among examined patients three phenotypes of connective tissue dysplasia were determined: (1) joint hypermobility syndrome; (2) increased dysplastic stigmatization and (3) increased, mostly visceral dysplastic stigmatization. The latter was more prevalent in females with osteoarthritis.
 Conclusion. High prevalence of connective tissue dysplasia criteria in primary osteoarthritis patients confirms the presence of dysplastic osteoarthritis phenotype and necessity of personalized attitude to patient management.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
