Abstract
Voltage-gated potassium channels (KVs) are activated in response to changes in the electrical membrane potential by coupling a voltage-sensing module with K+ selective pore. Toxins targeting the channel pore can interfere with ion permeation by physically occluding the pore (‘plug mechanism’), by inducing a collapse of the selectivity filter (‘pore-collapse mechanism’), or by trapping the ions in ectopic sites formed at the toxin-channel interface (‘lid mechanism’) to induce a complete channel block.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
