Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy

Abstract

INTRODUCTION PART A. THE STUDY POPULATION AND METHODS (Andrew E. Czeizel) I. The Hungarian Congenital Abnormality Registry (HCAR) II. The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) III. Preterm birth and low birth weight newborns IV. The Budapest Monitoring System of Self-poisoning Pregnant Women PART B. RESULTS OF STUDIES AND THEIR INTERPRETATION (Nandor Acs and Ferenc Banhidy) I. Certain infectious and parasitic diseases II. Neoplasms III. Diseases of blood and blood-forming organs IV. Endocrine, nutritional and metabolic diseases V. Mental and behavioural disorders VI. Diseases of the nervous system VII. Diseases of eye and adnexa VIII. Diseases of ear and mastoid process IX. Diseases of the circulatory system X. Diseases of the respiratory system XI. Diseases of the digestive system XII. Diseases of skin and subcutaneous tissue XIII. Diseases of the musculoskeletal system and connective tissue XIV/A. Diseases of urinary tract XIV/B. Diseases of genital organs XV. Pregnancy, childbirth and puerperium XVI. Congenital malformations, deformities and chromosomal abnormalities PART C: SUMMARY OF RESULTS AND RECOMMENDATIONS (Nandor Acs, Ferenc Banhidy and Andrew E. Czeizel) A/ Association of maternal diseases during pregnancy with higher risk of congenital abnormalities (CAs) in their children I. High fever related maternal diseases during pregnancy and CAs in their offspring II. Confirmed associations of maternal diseases with CA III. Unexpected associations of maternal diseases during pregnancy with a higher risk of CA in their children IV. Teratogenic potential of related drugs treatment V. Maternal diseases with preventive effect of CAs VI. Primary prevention of CAs B/ Association of maternal diseases withthe higher risk of preterm birth (PB) and low birth weight (LBW) newborns I. Local causes II. Microbial causes III. Chronic maternal diseases during the study pregnancy IV. Pregnancy complications during the study pregnancy V. Prevention of PB and LBW newborns