Abstract
To clarify the possible molecular mechanism of cation unit conductance of poly(D,L-proline) across lipidic membranes, the structure and conformation of tetraproline derivatives with different configurational sequences in solid state, as well as in solution and in the presence of alkali and alkali-earth ions, were investigated using x-ray analysis, CD, and nmr spectroscopy. The tetraproline derivatives Boc(D-Pro-L-Pro-L-Pro-D-Pro)OBg and Boc(L-Pro)4OBg show very different conformational versatilities in solutions as well as different propensities to form complexes with Ca2+ ion. This is interpreted, based on previous evidence, as due to different abilities to form ion complexing cavities. © 1998 John Wiley & Sons, Inc. Biopoly 45: 257–267, 1998
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