Abstract
AbstractDNA B−Z transitions play an important role in biological systems and have attracted much attention in DNA nanotechnology. DNA and its analogues have also been used as templates to construct helical chromophore associates with π‐interactions. We prepared DNAs with consecutive non‐nucleoside pyrene residues in the middle of d(CG) repeat sequences. The pyrene‐labelled DNAs adopted a unimolecular hairpin structure, in which the pyrenes associated in the loop region. They exhibited inversion of exciton‐coupled circular dichroism signals that can be ascribed to pyrene association through a DNA B−Z transition. This indicates that the conformation of pyrene associates can be switched from right to left by the DNA B−Z transition. The fluorescence of the pyrene‐labelled DNA changed when switching the association. Thus, pyrene‐labelled DNA can be utilized as a chiroptical molecular switch.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
