Conformational and electronic preferences in rhodium(II) carboxylate and rhodium(II) carboxamide catalyzed carbon-hydrogen insertion reactions of N,N-disubstituted diazoacetoacetamides

Abstract

Conformational preferences dominate electronic influences in governing regioselectivity for catalytic C-H insertion reactions of diazoacetoacetamides and allow the construction of β-lactams by insertion α and β to an ester functional group.