Abstract
The human ether-à -go-go-related gene (hERG) K+ channel has a crucial function in cardiac repolarization and mutations or channel block can give rise to long QT syndrome and catastrophic ventricular arrhythmias. The cytosolic assembly formed by the N-terminal Per-Arnt-Sim (PAS) and C-terminal cyclic nucleotide binding homology (CNBh) domains is the defining structural feature of hERG and related KCNH channels. However, the molecular role of these two domains in channel gating remains unclear. We have previously shown that single-chain fragment variable (scFv) antibody fragments can modulate hERG function by binding to the PAS domain.
Full Text
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call