Abstract
Cobalamin deficiency is common in adults. It must be suspected in case of abnormal blood counts (macrocytosis, hypersegmented neutrophils, pancytopenia) or unexplained neurological symptoms (cognitive impairment, ataxia, paresthesia), especially among vulnerable populations such as older adults, alcoholics, vegetarian or undernourished patients. The diagnosis is confirmed by a serum level of cobalamin lower than 200pg/ml. The main causes are food-cobalamin malabsorption, pernicious anemia (Biermer's disease) and, less frequently, malabsorption and inadequate intake. The treatment consists in the parenteral or oral administration of cobalamin.
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