Abstract
Up to now, the clinical treatment of spinal cord injury (SCI) to recover the locomotion function, sensory function, and autonomic function of patients is a global medical challenge. In this study, based on the excellent effects of Tetramethylpyrazine (TMP) on regulating pathological micro-environment, we designed a new injectable conductive hydrogel consists of water-soluble polypyrrole (Ppy), agar, and TMP. The TMP@PA hydrogel has excellent physicochemical properties, bio-safety, and drug release ability, which can be injected into lesions in situ without secondary injury for SCI. Our in vivo and in vitro experiments have demonstrated that the TMP@PA hydrogel can not only fill the spinal cord cavity to reconstruct the electrical conduction pathway but also release TMP continuously to inhibit ferroptosis by regulating nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy regulated by Yes-Associated Protein (YAP) to promote SCI repair. Collectively, TMP@PA hydrogel may be an effective tissue engineering scaffold to treat SCI with highly promising clinical applications.
Published Version
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