Abstract
1. A number of CNS-active drugs was tested for action on conditioned suppression (CER) in rats in the experimental procedure devised by Estes and Skinner. Thirsty rats were rewarded with water on pressing a lever at intervals of not less than 5 seconds. The conditioning signal lasted 10–60 seconds and was always followed by an unavoidable electric shock. The CER — the decrease in lever-pressing activity during signals — was very pronounced in untreated animals. 2. Chlordiazepoxide inhibited the diminution in the lever-pressing rate during signals. After 20 mg/kg by mouth the CER was completely abolished. 24 hours after treatment the CER reappeared in a fully pronounced form. 3. Similar effects were produced by phenobarbital, methylphenobarbital, barbital, aprobarbital, amobarbital and chloral hydrate. Meprobamate and carisoprodol were less active. Chlorpromazine, cyclobarbital, hexobarbital, methylpentinol, ethanol, mephenoxalone, amphetamine and morphine were inactive.
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