Abstract
The aim - to study and to analyze the indicators of the humoral link of the immune system in patients with systemic connective tissue diseases with chronic activated HSV 1/2 infection and to assess the effect of the revealed disorders on the development of autoimmune pathology.
 Materials and methods. We examined 380 patients with systemic diseases of the connective tissue (systemic lupus erythematosus, systemic vasculitis, rheumatoid arthritis, psoriasis) with chronic HSV 1/2 infection at the age of 21-67 years. In 45 of them, using the modern molecular genetic diagnosis of herpes simplex, the active phase of chronic HSV 1/2 infection was verified based on the results of the polymerase chain reaction, and in the other 335, the latent phase was verified. The control group consisted of 20 healthy individuals of the appropriate age and gender. In patients with systemic connective tissue diseases with chronic HSV 1/2 infection, the humoral immunity indices were studied: levels of complement component C3 and IFN-a in saliva and blood and acquired: concentration of common major immunoglobulinins: IgG, IgM IgA, IgE; specific IgM and IgG to HSV 1/2; levels of cryoglobulins, cryofibrinogen, CІC in serum. Statistical processing of the results of the study was carried out using generally accepted methods of variation statistics.
 Results. In patients with systemic diseases of connective tissue with chronic HSV 1/2 infection, activation of the humoral immunity was detected, it was especially evident in the active phase of the infection and was characterized by an increase in the antibody production of specific IgM HSV 1/2 and IgG HSV 1/2, аn increase in the levels of CIC, IgM, IgA and IgE, cryoprecipitation proteins, IFN-a in the blood. In the latent phase of HSV 1/2 infection the levels of IgG production of HSV 1/2, IgE, CEC, cryofibrinogen and cryoglobulins in the blood serum of these patients increased.
 Conclusions. The presence of chronic activated HSV 1/2 infection in patients with systemic diseases of the connective tissue causes activation of the humoral immunity, creates the conditions for the development of autoimmune processes.
Highlights
We examined 380 patients with systemic diseases of the connective tissue with chronic Herpes simplex virus (HSV) 1/2 infection at the age of 21-67 years
In 45 of them, using the modern molecular genetic diagnosis of herpes simplex, the active phase of chronic HSV 1/2 infection was verified based on the results of the polymerase chain reaction, and in the other 335, the latent phase was verified
In patients with systemic diseases of connective tissue with chronic HSV 1/2 infection, activation of the humoral immunity was detected, it was especially evident in the active phase of the infection and was characterized by an increase in the antibody production of specific IgM HSV 1/2 and IgG HSV 1/2, аn increase in the levels of CIC, IgM, IgA and IgE, cryoprecipitation proteins, IFN- in the blood
Summary
У хворих на СЗСТ з латентною фазою HSV 1/2 інфекції виявлено зростання, у порівнянні зі здоровими, титру IgЕ у 1,6 разів (р
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