Abstract
Molecular Imaging Condensin is thought to regulate genome architecture by creating DNA loops. Terakawa et al. used single-molecule imaging to show that yeast condensin is a highly processive mechanochemical motor capable of translocating along DNA (see the Perspective by Nasmyth). Their findings elucidate how the rapid ATP hydrolysis–dependent motor activity of condensin provides the driving forces necessary to support three-dimensional chromosome organization and compaction through a loop extrusion mechanism. Science , this issue p. [672][1]; see also p. [589][2] [1]: /lookup/doi/10.1126/science.aan6516 [2]: /lookup/doi/10.1126/science.aap8729
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