Concomitant symptom and medicine related exacerbation in myasthenia gravis: how to analyse the clinical causal relationship

Abstract

Symptoms of autonomic nervous system involvement and exacerbation of weakness after taking several medicines are often seen in myasthenia gravis (MG). The autonomic nervous system involvement may be a part of clinical manifestation of MG or may be caused by concomitant diseases in MG. The exacerbation of weakness may be direct effects of medicine on neuromuscular junction or complex impact resulting from various mechanisms. To elucidate the concurrence, association or causal relationship between events not only helps to explore the mechanism of diseases, but also to solve the clinical problems. DOI：10.3969/j.issn.1672⁃6731.2012.02.008