Abstract
This chapter examines some remarks on lipoprotein metabolism, apolipoproteins, and lipid constituents. All lipoproteins found in the plasma are present in the lymph. The interstitial space is about three times the plasma space so a substantial portion of the lipoproteins is present in the interstitium. The VLDL synthesis of the isolated hepatocytes corresponds to the rate measured in vivo . The composition of VLDL is similar to the particles synthetized in vivo , but it does contain less cholesterine and C apoprotein. The in vitro VLDL synthesis can be blocked by inhibitors of protein synthesis and by blocking the microtubular system. Feeding with sucrose causes a long term synthesis increase; however, the addition of fatty acid to the medium brings about a short time elevation of the VLDL secretion.
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