Abstract
SARS-CoV-2 binds to the host cells through its spike glycoprotein, making it a key target for therapeutic antibodies. The anchoring of the spike to the viral envelope through the stalk domain allows it to function as extended viral antennae for recognition by the host cell surface receptors, and the construction of the complete membrane-bound spike model and description of its dynamics remain the first and most critical steps in understanding the working of this key component of the viral infection machinery.
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