Abstract
In field-flow fractionation with secondary chemical equilibria (SCE-FFF), small solutes can be separated according to their distribution coefficient between a carrier additive species affected by the applied field and the bulk carrier. Due to its interaction with the applied field, the average additive concentration within the FFF channel is generally significantly larger than in the carrier reservoir and becomes so high that additive-additive interactions cannot be neglected. A recent retention model of FFF at finite concentrations is applied to SCE-FFF. In contradistinction with previous theories in which additiveadditive interactions were not accounted for, it is found that the retention time of a given solute goes to a maximum when the additive concentration in the carrier increases. Published SCE-FFF experimental data are examined in light of this model. The potential of this FFF operating mode and guidelines for optimizing the separation are discussed
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
