Abstract
Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, KoreaReceived May 12, 2014, Accepted July 2, 2014A series of 3,4-dihydroquinazoline derivatives with anti-cancer activities against human colon cancer HT-29cell were subjected to three-dimensional quantitative structure-activity relationship (3D-QSAR) studies usingthe comparative molecular similarity indices analysis (CoMSIA) approaches. The most potent compound,BK10001 was used to align the molecules. As a result, the best prediction was obtained with CoMSIAcombined electrostatic, hydrophobic, and hydrogen-bond acceptor fields (q
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