Abstract
This study aimed to explore the application value of computed tomography (CT) imaging radiomics based on a sinogram-affirmed iterative reconstruction algorithm (SAFIRE) in the diagnosis of gastric cancer. 59 patients who were clinically diagnosed with gastric cancer were selected as research objects and arranged CT examinations. The images obtained were optimized by the SAFIRE for the staging of gastric cancer. The pathological biopsy results were used as the gold standard to evaluate its diagnostic effect and compared with the filtered back-projection (FBP) method. The results showed that the carrier-to-noise ratio (CNR) (0.979) and signal-to-noise ratio (SNR) (0.967) of the CT image after the algorithm processing were significantly higher than those (0.781, 0.744) before ( P < 0.05 ). There was no significant difference in CT values between the FBP algorithm and S1, S2, and S3 ( P > 0.05 ); the area under the curve (AUC) (0.999) and sensitivity (0.98) of the CT training group under the SAFIRE algorithm for gastric cancer classification were higher than those of the verification group (0.958, 0.92). The preoperative CT staging kappa value was consistent with the postoperative pathological diagnosis of 0.882. CT images guided by SAFIRE can objectively and noninvasively assess the tumor asymmetry, discover additional information from subjective evaluation beyond the naked eye, and perform reasonable staging diagnosis of gastric cancer, which was useful for clinicians to develop high-quality individualized treatment plans.
Highlights
Gastric cancer is a common disease with high morbidity and mortality in China, which is common in the gastrointestinal tract and primary malignant tumors
computed tomography (CT) scan was performed on all patients with gastric cancer, sinogram-affirmed iterative reconstruction algorithm (SAFIRE) was used for treatment in clinical staging diagnosis of gastric cancer, and pathological changes of the normal stomach were studied on each patient, with pathological diagnosis results as the gold standard
A single analysis of variance was adopted, and the results showed that there was no significant difference between the filtered back-projection (FBP) algorithm image and the SAFIRE image in the measured average CT values of each part (P > 0.05) (Figures 3 and 4)
Summary
Gastric cancer is a common disease with high morbidity and mortality in China, which is common in the gastrointestinal tract and primary malignant tumors. E degree of histological differentiation is an important factor. E lower the degree of differentiation, the higher the degree of malignancy, and the worse the prognosis. Decourcy et al found that gastric cancer with different degrees of differentiation had different biological behavior and chemotherapy sensitivity. E excision rate of early gastric cancer is high, up to 90%. Radical surgery is the main treatment for early gastric cancer. Palliative surgery is adopted when the tumor cannot be completely excised in advanced gastric cancer. E choice of business scope and business mode has a great impact on the life of patients because the stomach plays a very important role in the entire digestive system. In addition to the production of gastric juice and digestive enzymes, there are many kinds of internal factors such as the secretion of functional cells and parietal cells, which are important factors in the production of red blood cells [6, 7]
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