Abstract
Human plasmodial malaria is a severe infection of the erythrocytes with significant morbidity and mortality. The dimensional changes induced by P.vivax malaria parasites in erythrocytes in human blood are prominent and varies with the degree of parasitaemia. Aggregation of erythrocytes is a common finding in patients infected with malaria. The changes in the shape of erythrocyte and its cytoplasm have been determined by shape descriptors and gray scale variation of the cytoplasm by microscopic imaging and image processing tools. The computerized shape analysis is carried out from the digital images obtained under microscope by shape descriptors based on projected area, perimeter and form factor,as measured by processing of images of erythrocytes in patients undergoing treatment for malaria. The changes induced in the cytoplasm by the malaria parasite are determined by the scanning of erythrocytes images along the horizontal diameter. The levels of aggregation of erythrocytes corresponding to the levels of infection, is measured and compared with normal samples. Growth of malaria parasite within the cytoplasm of the erythrocyte has also been measured. The measurable deviations in various other entities of the erythrocytes in a malaria patients using image processing techniques, has also been discussed.
Highlights
Malaria is a caused by parasites called plasmodia
Despite the massive efforts put by the World Health Organization in the late 1950s and 1960s to eradicate malaria worldwide, the disease still remains a major tropical health problem, infecting over 200 million people worldwide
The clinical symptoms of malaria are a consequence of infection of human erythrocytes
Summary
Malaria is a caused by parasites called plasmodia. Plasmodia parasites are transmitted between humans by the bite of an infected anopheles mosquito. It causes serious effects on human beings. Malaria is one of the most serious parasitic infections of human. Despite the massive efforts put by the World Health Organization in the late 1950s and 1960s to eradicate malaria worldwide, the disease still remains a major tropical health problem, infecting over 200 million people worldwide. In India malaria is a major health parasitic disease, where every year at least 2 million cases are reported. Malaria is one of the most serious public health problems in India and is prevalent in the whole of the country except areas above 1800 meters
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