Abstract
AbstractThe Staudinger cycloaddition reaction represents an efficient way to readily afford β‐lactams from ketenes and imines in an asynchronous [2+2] process. Herein, a computational evaluation of the scope of the Staudinger cycloaddition reactions was undertaken by using simplified molecular models. The results pointed out that the kinetics and thermodynamics of the reaction are independent of the substituents of the imine and are essentially determined by the steric and electronic nature of the substituents of the α‐position of the ketene, being the latter the one that exerts a more dominant effect on the global feasibility of the reaction.
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