Computational analysis of radon progeny deposition patterns in the human respiratory system

Abstract

In the last year, the use of computational fluid dynamics (CFD) techniques has gained prominence as a powerful tool for modeling biological phenomena and influencing the design of biomedical devices. In this study, we utilized a computational fluid dynamics (CFD) model to simulate airflow and the deposition of aerosol particles within the human respiratory tract. To achieve this, we meticulously constructed a 3D model of the human tracheobronchial airways using SolidWorks software. Our computational analyses encompassed a range of breathing conditions, ranging from 15 to 60 (L/min). Through the application of discrete phase modeling (DPM), we investigate the behavior of two-phase flow dynamics. Our focus lies in the examination of aerosol particles, with diameters ranging from 1 to 10 (μm), in order to evaluate the influence of aerosol particle size on deposition rates. Our findings encompass velocity contour maps, deposition rates of aerosol particles, and insights into the process of aerosol particle entrapment at various locations within the respiratory tract. Our study reveals a direct correlation between higher inhalation rates and larger aerosol particle sizes, resulting in increased deposition rates. Additionally, we observe a heightened deposition of aerosol-particles at bronchi region. These computational results hold significant value in estimating the distribution of doses resulting from radon progeny exposure in distinct anatomical regions of the respiratory tract.