Abstract
5-(3-Methylbutyl) 5-propyl barbituric acid could a priori undergo hepatic oxidation on either isoamyl or propyl side chains. Models of metabolites were synthesized and the barbiturate was administered to dogs and rats. Only a γ-hydroxy derivative was recovered in urine. This observation confirms the easy hydroxylation of the tertiary carbon in the 3-methyl-butyl group and establishes that the propyl side chain is less sensitive to oxidation than the ethyl side chain of amobarbital.
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