Abstract
This work was aimed to study the risk factors and prognostic treatment for acute ischemic stroke (AIS) patients with early neurological deterioration (END) after intravenous thrombolytic therapy via compressed sensing algorithm-based magnetic resonance imaging (CS-MRI). 231 patients who were diagnosed with AIS were selected, and the final involved number of patients was 182. Patients with AIS were treated with intravenous thrombolysis with alteplase within 4.5 hours of onset. After treatment, patients with early neurological deterioration were defined as the deteriorating group and those without early neurological impairment were defined as the nondeteriorating group. In univariate analysis, hypertension, white blood cell count, and National Institutes of Health Stroke Scale (NIHSS) score were correlated with the occurrence of END. Under the CS-MRI theory, the two groups of patients were evaluated for middle cerebral artery basal ganglia infarction and internal watershed infarction. After univariate analysis, the P < 0.1 variables were taken as the independent variable, and the binary logistic regression model was adopted for multivariate regression analysis. It was disclosed that NIHSS score was not correlated with the occurrence of early neurological function deterioration, while homocysteine was. Hypertension, white blood cell count, homocysteine, and NIHSS score were risk factors for END. The image analysis revealed that the incidence of deteriorating basal ganglia infarction group was lower relative to the nondeteriorating group, and the incidence of watershed infarction was higher in the deteriorating group versus the nondeteriorating group. The image analysis suggested that predicting the occurrence of END through risk factors can actively provide endovascular treatment for patients with AIS.
Highlights
acute ischemic stroke (AIS), known as cerebral infarction, refers to the stenosis or occlusion of the blood supply arteries of the brain and is the general term for brain tissue necrosis caused by insufficient blood supply to the brain [1]
According to the exclusion criteria, it was determined that 182 cases were selected, 75 patients who received intravenous thrombolytic therapy with early functional deterioration were defined as the deterioration group, and 107 patients without early functional deterioration were defined as the nondeteriorating group. e study was approved by the Medical Ethics Committee of Hospital, and the patients and their families understood the research situation and signed an informed consent form
E binary logistic regression model was adopted for multivariate regression analysis, and it was found that the National Institutes of Health Stroke Scale (NIHSS) score was not correlated with the occurrence of early neurological deterioration (END), and there was a certain correlation between homocysteine and the occurrence of END
Summary
AIS, known as cerebral infarction, refers to the stenosis or occlusion of the blood supply arteries of the brain and is the general term for brain tissue necrosis caused by insufficient blood supply to the brain [1]. END after intravenous thrombolytic therapy for AIS refers to neurological function of patients with stroke, after intravenous thrombolytic therapy improves in a short period of time and fluctuates or deteriorates in a stepped manner [2]. END indicates a longterm poor prognosis in patients with AIS. Few literatures have pointed out predictive indicators and methods for END. The traditional basic particle swarm algorithm needs to collect a large amount of data, which prolongs the time of data collection, and the influence of noise and artifacts will interfere with the image [4]. Erefore, reducing the number of data collection, reducing collection time, and forming streamlined and fast MRI images have become the major problems that modern medicine continues to solve. Some studies have proposed that compressed sensing theory is currently one of the hot topics in the field of information engineering [5], which
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