Abstract
Objective : to analyze short-term and long-term outcomes of surgical, combination, and comprehensive treatment in patients with metastatic rectal cancer. Materials and methods . We performed a retrospective analysis of prospectively collected data on the outcomes of rectal cancer patients receiving surgical, combination (surgery + chemotherapy), or comprehensive (chemoradiotherapy + surgery + chemotherapy) treatment in the Department of Proctology at the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, between 1999 and 2015. We assessed overall survival, frequency of postoperative complications, postoperative death rates and frequency of complications associated with chemoradiotherapy. Results . The study included 366patients that were divided into 3 groups according to the treatment strategy. The 2-year survival rate was 83 % in group 3 (comprehensive treatment) vs 40 % in groups 1 and 2. Median survival was 43 months in group 3 compared to 18 and 14 months in groups 2 and 1 respectively. The number of postoperative complications was 19 %, 13.4 %, and 15.1 % in groups 1, 2 and 3 respectively. There was one postoperative death (1.1 %) in group 3. Conclusion . Comprehensive treatment significantly improves overall survival of rectal cancer patients without increasing the risk of postoperative complications.
Highlights
Цель исследования – изучить непосредственные и отдаленные результаты хирургического, комбинированного и комплексного лечения больных метастатическим раком прямой кишки
We performed a retrospective analysis of prospectively collected data on the outcomes of rectal cancer patients receiving surgical, combination, or comprehensive treatment in the Department of Proctology at the N.N
Frequency of postoperative complications, postoperative death rates and frequency of complications associated with chemoradiotherapy
Summary
Цель исследования – изучить непосредственные и отдаленные результаты хирургического, комбинированного и комплексного лечения больных метастатическим раком прямой кишки. Данная работа основана на ретроспективном анализе проспективно собранной базы данных результатов лечения больных раком прямой кишки, которым проводилось хирургическое, комбинированное (операция и химиотерапия) и комплексное (химиолучевая терапия, операция и химиотерапия) лечение в проктологическом отделении ФГБУ «Национальный медицинский исследовательский центр онкологии им. Комплексный подход лечения позволяет значительно увеличить показатели общей выживаемости больных метастатическим раком прямой кишки без повышения риска послеоперационных осложнений. We performed a retrospective analysis of prospectively collected data on the outcomes of rectal cancer patients receiving surgical, combination (surgery + chemotherapy), or comprehensive (chemoradiotherapy + surgery + chemotherapy) treatment in the Department of Proctology at the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, between 1999 and 2015.
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