Abstract
When prescribing a vitamin‑mineral complex or a drug containing docosahexaenoic acid (DHA) to a pregnant, lactating mother and child, it is expected to receive the effect from the subsidy of this polyunsaturated fatty acid (omega‑3 PUFA). In the case when the preparation contains additional impurities, the magnitude and nature of the effect may differ from the expected ones. In this work, we conducted a comprehensive study of the composition of 11 omega‑3 PUFA preparations with chromatographic determination of more than 40 metabolites of fatty acids and other compounds. The obtained data on the composition of the extracts were analyzed using modern methods of intellectual analysis. As a result, quantitative markers were obtained that made it possible to separate preparations based on standardized omega‑3 PUFAs from less standardized ones based on chromatographic analysis of the fatty acid composition of the preparations: marker ‘EPA + DHA’, marker ‘ω6 + ω11’ and standardization coefficient evaluating the conformity of measured levels of omega‑3 PUFAs to manufacturer declared. Based on the data obtained, highly standardized (Elevit Feeding, Omacor), medium and low standardized preparations were selected. It is recommended to take these data into account when prescribing and choosing vitamin complexes for nursing women, preferring highly standardized ones.
Highlights
it is expected to receive the effect from the subsidy of this polyunsaturated fatty acid
the magnitude and nature of the effect may differ from the expected ones
we conducted a comprehensive study of the composition of 11 omega‐3 PUFA preparations
Summary
Таблица 2 Соединения, найденные в исследованных образцах в результате проведения хроматографического анализа. Methyl nicotinate Octadecanoic acid, ethyl ester Octadecanoic acid, methyl ester. Pentadecanoic acid, methyl ester Tetradecanoic acid, ethyl ester Tetradecanoic acid, methyl ester Tetradecanoic acid, methyl ester. Метилникотинат Стеариновая к-та, этиловый эфир Стеариновая к-та, метиловый эфир Каприловая к-та, метиловый эфир. Миристиновая к-та, этиловый эфир Миристиновая к-та, метиловый эфир Миристиновая к-та, метиловый эфир 12-метил-тридеканоевая к-та, метиловый эфир 12-метил-тридеканоевая к-та, метиловый эфир Тридеканоевая к-та, метиловый эфир. 1 являются эфиры ЖК, а препаратов 2–4, 12, (рыбьего жира), и 16 — триглицериды В настоящей работе мы представляем результаты количественного хроматографического анализа 11 образцов омега‐3 ПНЖК, полученных на основе экстрактов жира рыб. 1. Отметим, что все исследованные препараты изготовлялись на основе жира тех или иных сортов рыбы в качестве исходного сырья
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