Comprehensive Multiplexed Therapy for Severe Nodulocystic Acne in Puberty

Ichiro Kurokawa

doi:10.4172/2375-4273.1000160

Abstract

Nodulocystic acne (NCA) usually develops subcutaneous epidermal cyst, granuloma, subcutaneous abscess, hypertrophic scar, keloids, and draining sinus. The pathogenesis of NCA is still unclear. Similar to NCA, acne conglobata (AC) is found in men predominantly with oily skin [1]. Lesions of AC begin in early puberty and culminate in late adolescent [1]. AC is one of the most therapy-resistant diseases which do not respond to usual treatments for acne vulgaris. In Europe and USA, isotretinoin has been used for the treatment for NCA and AC [2]. However, it is unavailable to use in Japan. Therefore, treatment for NCA in Japan is very difficult. Two cases with NCA have been treated with comprehensive therapy with incision, oral and topical antimicrobials, oral tranilast, topical benzoyl peroxide (BPO) and skin care.

Highlights

Nodulocystic acne (NCA) usually develops subcutaneous epidermal cyst, granuloma, subcutaneous abscess, hypertrophic scar, keloids, and draining sinus
acne conglobata (AC) is one of the most therapy-resistant diseases which do not respond to usual treatments for acne vulgaris
Two cases with NCA have been treated with comprehensive therapy with incision, oral and topical antimicrobials, oral tranilast, topical benzoyl peroxide (BPO) and skin care

Summary

Introduction

Nodulocystic acne (NCA) usually develops subcutaneous epidermal cyst, granuloma, subcutaneous abscess, hypertrophic scar, keloids, and draining sinus. Comprehensive Multiplexed Therapy for Severe Nodulocystic Acne in Puberty Ichiro Kurokawa* Department of Dermatology, Acne Clinical Research Center, Meiwa Hospital, Japan Treatment for NCA in Japan is very difficult. Two cases with NCA have been treated with comprehensive therapy with incision, oral and topical antimicrobials, oral tranilast, topical benzoyl peroxide (BPO) and skin care.

Results

Conclusion