Abstract
Multifunctional theranostic systems are a recent important development of medical research. We combined the characteristics of near-infrared luminescent quantum dots and thermosensitive magnetoliposomes to develop a multifunctional nano-diagnostic material. This system is based on near-infrared magnetic thermosensitive liposomes, which encapsulate drugs and can control drug localization and release. After incubating cancer cells with the liposomes, the state of the cells was analyzed in real time by near-infrared imaging. Cell viability was significantly inhibited by heat treatment or alternating magnetic field treatment, which thus improved the anti-cancer properties of the liposomes. In the future, by combining near-infrared imaging technology and an external high-frequency alternating magnetic field, we could not only detect cancer cells noninvasively but also conduct image-guided treatments for cancer.
Highlights
Cancer is known as the silent killer that affects the health of millions of people around the world [1].Conventional chemotherapy is one of the most widely used clinical methods to improve the chances of patient survival [2,3]
In order to further evaluate the diameter of the liposomes, the morphologies and sizes of blank liposomes (BLs), PTX-Ls, and PTX–NMTSLs were observed by TEM (Figure 2a,b,c)
After incubation for 2 h, the fluorescent images indicated that PTX–NMTSLs had gathered around the cells and entered the cytoplasm (Figure 5a,c), while after 4 h, PTX–NMTSLs had entered the nucleus (Figure 5b,d). This experiment showed that PTX–NMTSLs was rapidly absorbed by the cells, and allowed following the process of cellular uptake in real time
Summary
Cancer is known as the silent killer that affects the health of millions of people around the world [1]. Pradhan et al [21] successfully demonstrated that thermosensitive magnetoliposomes containing magnetoliposomes containing doxorubicin could be used for cancer hyperthermia and drug delivery. Thermosensitive liposomes were the basic material to prepare thermosensitive liposomes loaded with PTX, near-infrared quantum dots, and magnetic nanoparticles (PTX–NMTSLs). The response of cancer cells to PTX–NMTSLs could be observed by near-infrared fluorescence imaging. When the liposomes accumulated in the target cells, damage of the liposome drug release were achieved by applying an alternating magnetic field (AMF) or external heating so to membrane structure and drug release were achieved by applying an alternating magnetic field generate high heat In this way, accuracy of disease diagnosis and treatment could be improved by (AMF) or external heating so to generate high heat.
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