Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis.

Emily K W Lo,Andrew P Feinberg,Kenneth P Olive,Kasper D Hansen,Ralph H Hruban,Elizabeth D Thompson,Adrian Idrizi,H Carlo Maurer,Brian M Mears

doi:10.1158/0008-5472.can-22-4052

Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis.

Emily K W Lo, Andrew P Feinberg + Show 7 more

Open Access

PDF Available

https://doi.org/10.1158/0008-5472.can-22-4052

Copy DOI

Export

Save

Cite

Journal: Cancer Research	Publication Date: Mar 29, 2023
Citations: 10	License type: cc-by

Affiliation: Johns Hopkins Medicine, Johns Hopkins University, Columbia University, Columbia University Irving Medical Center, Cancer Research Center, Rechts der Isar Hospital

#Comprehensive DNA Methylation Analysis #Pancreatic Intraepithelial Neoplasia Lesions #DNA Methylation #Analysis Of Landscapes #Pancreatic Lesions #Comprehensive Analysis #Comprehensive DNA Methylation #DNA Methylation Landscapes #Intraepithelial Neoplasia Lesions #Human PDAC

Abstract
Full-Text PDF
Similar Papers

Abstract

Listen

Analysis of DNA methylation landscapes provides insights into the cell-of-origin of PanIN lesions, clarifies the role of PanIN lesions as metaplastic precursors to human PDAC, and suggests potential targets for chemoprevention.

Full Text

Submitted Version (Free)

View/Download pdf

Published Version

Check institute access

Open DOI Link

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Similar Papers

Paper Title

Journal

Date

Author

View more papers

More From: Cancer Research

Paper Title

Journal

Date

Author

View more papers

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.

R Discovery Prime

Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis.