Abstract
Colon cancer (CC) is one of the most prevalent malignant tumours of the alimentary canal. It is unclear whether pyroptosis-related lncRNA expression is correlated with CC prognosis. We discovered 20 pyroptosis-related lncRNAs that were expressed differently in CC and normal colon tissues in our investigation. Based on differentially expressed genes (DEGs), we grouped all CC patients into two categories (Clusters 1 and 2). Cluster 1 was shown to be connected with a higher overall survival rate, upregulated expression of immune checkpoints, higher immunoscores, higher estimated scores, and immune cell infiltration. Using data from the Cancer Genome Atlas (TCGA), to create a multigene signature, the predictive significance of each lncRNA linked with pyroptosis for survival was assessed. A 9-lncRNA signature was established using the least absolute shrinkage and selection operator (LASSO) Cox regression method, and all CC patients in the TCGA cohort were classified into low-risk or high-risk groups. The low-risk CC patients had a much greater chance of survival than those in the high-risk group. The risk score is an independent prognostic indicator for predicting survival. In addition, risk characteristics are linked to immune characteristics. In summary, pyroptosis-related lncRNAs can be used to predict CC prognosis and participate in tumour immunity.
Highlights
Colon cancer (CC) is one of the most frequent tumours globally, accounting for 6% of global tumour incidence in 2020, and the morbidity and mortality rate ranked fifth among cancers in 2020 [1]. e prevalence of CC has reduced marginally in the last few years, but the increase in the prevalence rate among young people has become more visible [2]
All CC data were divided into subgroups based on the expression of prognostic pyroptosis-related long noncoding RNAs (lncRNAs) using the “ConsensusClusterPlus” package. en, we analysed the difference in survival probability, expression, and coexpression of immune checkpoint inhibitors (PD-1, PD-L1, and CTLA-4), immune cell infiltration, and immune cell-related score in all clusters
We reviewed the association between tumour immunity, clinicopathological characteristics, risk scores, and immune checkpoint expression, which is momentous in tumour [44]. e immune cell enrichment data come from the TIMER2.0 database [45]
Summary
Colon cancer (CC) is one of the most frequent tumours globally, accounting for 6% of global tumour incidence in 2020, and the morbidity and mortality rate ranked fifth among cancers in 2020 [1]. e prevalence of CC has reduced marginally in the last few years, but the increase in the prevalence rate among young people has become more visible [2]. Pyroptosis is a type of programmed cell death (PCD) and is defined by the morphology of inflammatory cell death. It was first observed in 1992 [6], and Boise and Collins named it pyroptosis in 2000 [7]. E thermophilic cells create a significant number of vesicles first, as seen under the electron microscope. When these vesicles are formed, holes are formed in the cell membrane. Pyroptosis has been implicated in tumour development, mortality, and the tumour immune microenvironment in numerous studies [15]. Increasing data are proving that pyroptosis is important in the onset and development of cancers [16,17,18,19]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
