Abstract
Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and its incidence is obviously increasing. The NT5DC family has been shown to be involved in the progression of many tumors. However, the biological function of NT5DC family members in HCC is still not well understood. Methods Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, Kaplan–Meier plotter, cBioPortal, GeneMANIA, Metascape, and TIMER were applied to assess the biological function of NT5DC family members in HCC. Results Most of the NT5DC family members were highly expressed in HCC. High expression of NT5C2, NT5DC2, and NT5DC3 was closely associated with higher tumor stage and poor overall survival (OS). In addition, high NT5DC2 and NT5DC3 expression also predicted poor disease-free survival (DFS). Enrichment analysis revealed that the NT5DC family in HCC mainly involved the IMP metabolic process, purine ribonucleoside monophosphate metabolic process, and purine nucleoside monophosphate metabolic process. The expression of NT5DC family members was closely related to the infiltration of some immune cells, such as B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells. Conclusion Our findings provided new insights into the biological function and prognostic value of NT5DC family members in HCC.
Highlights
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and the second leading cause of cancer death [1]
E NT5DC family is a kind of evolutionary conserved 5′-nucleotidase, which can catalyze the hydrolysis of nucleotides in cells [6]. e NT5DC family members include NT5C2, NT5DC1, NT5DC2, NT5DC3, and NT5DC4, and they all contain a haloacid dehalogenase motif localized in the N-terminus of these proteins [6]
We evaluated the association between NT5DC family gene mutation and HCC patient prognosis. e results displayed that NT5DC family gene mutation was associated with adverse disease-free survival (DFS) (P 0.0365) (Figure 7(c))
Summary
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and its incidence is obviously increasing. e NT5DC family has been shown to be involved in the progression of many tumors. E NT5DC family has been shown to be involved in the progression of many tumors. The biological function of NT5DC family members in HCC is still not well understood. Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, Kaplan–Meier plotter, cBioPortal, GeneMANIA, Metascape, and TIMER were applied to assess the biological function of NT5DC family members in HCC. Most of the NT5DC family members were highly expressed in HCC. High expression of NT5C2, NT5DC2, and NT5DC3 was closely associated with higher tumor stage and poor overall survival (OS). E expression of NT5DC family members was closely related to the infiltration of some immune cells, such as B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells. Our findings provided new insights into the biological function and prognostic value of NT5DC family members in HCC
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