Abstract
Summary The author studies the modifications in the nephronic proximal convoluted tubule resulting from administration of water via a gastric sound once of several times daily during one or several days. By morphological and karyometric methods the author observes nuclear and cellular reduction. Upon continuation of the treatment, one notes a stable picture characterised by an evident and continuous brush borden, absence of cytoplasmic granulations and inclusions, and a prevalently rod-like chondriome. The tubule shows also a reduction of its lumen, this being devoid of all casts normally present in this species. The literature discussion allows one to recognise, from the above aspects, a reduced activity of the epithelium as a consequence of filtrate dilution and, accordingly, smaller work in the resorption of solutes. The author remarks also on the physiomorphological characteristics, specific for the mouse kidney, and relates the normal picture, marked by indefinite brush border, cytoplasmic granulatio...
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