Complicated oscillations and non-resonant double Hopf bifurcation of multiple feedback delayed control system of the gut microbiota

Abstract

In this paper, we consider the complex dynamics of a novel mathematical model for a feedback control system of the gut microbiota, which was proposed by Dong, et al. The main work of the present paper is to study the effect of antibiotics injection on the gut microbiota through some dynamical methods, such as double Hopf bifurcation analysis and so on. We first use DDE-BIFTOOL to find the non-resonant double Hopf bifurcation points of the system, and draw the bifurcation diagram with two bifurcation parameters, τ1 and τ2, i.e., respective measurement delays. Then we study small perturbations of two delay differential equations at these double Hopf bifurcation points, and the method of multiple scales is employed to obtain two common complex amplitude equations. By analyzing the amplitude equations, we can derive the classification and unfolding of these double Hopf bifurcation points. Finally, we verify the results by numerical simulations. We find more complicated dynamic behaviors of the system via analytical method. For example, there exists stable equilibrium, stable periodic solution or even the co-existing stable periodic solutions in respective region. And the numerical simulations are consistent with the analytic results, meanwhile it implies that the MMS is effective and accurate. All complex dynamical phenomena found in the present paper can be very helpful for the researchers to understand the mechanism of the system of gut microbiota. And it is also very significant to microbiology and engineering control. It reveals that the measurement delays can induce the complicated dynamics in this system and to the ends of excellent performance, we should take the proper values of these delays.