Abstract
The slightly water-soluble cancer chemopreventive polyphenol resveratrol (Res) and its inclusions with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-CD) have been investigated. The stoichiometric ratios and stability constants have been determined by phase-solubility measurements. In all cases 1:1 complexes are formed. The inclusion ability of HP-CD is larger than that of β-CD. The antioxidant activity of the Res complexes has been determined by the scavenging of the stable radical DPPH . The scavenging capacity of the two complexes increases with increasing concentration of cyclodextrins. Res/HP-CD complex shows a higher scavenging capacity than Res/β-CD complex. The antioxidant activity of Res in free form has little difference with Res in complexed form at the same concentration.
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